H2N2V1, Main, Exploration, bibRecord, 000499

[A preclinical trial of the reassortant influenza virus vaccine strain A/17/Quail/Hong Kong/97/84 (H9N2)].

Identifieur interne : 000499 ( Main/Exploration ); précédent : 000498; suivant : 000500

[A preclinical trial of the reassortant influenza virus vaccine strain A/17/Quail/Hong Kong/97/84 (H9N2)].

Auteurs : Yu A. Desheva ; T A Smolonogina ; L G Rudenko

Source :

Voprosy virusologii [ 0507-4088 ] ; 2015.

RBID : pubmed:26665434

Descripteurs français

KwdFr :
- Animaux, Femelle, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Souris, Souris de lignée CBA, Sous-type H9N2 du virus de la grippe A (immunologie), Vaccins antigrippaux (immunologie), Évaluation préclinique de médicament.
MESH :
- immunologie : Infections à Orthomyxoviridae, Sous-type H9N2 du virus de la grippe A, Vaccins antigrippaux.
- Animaux, Femelle, Infections à Orthomyxoviridae, Souris, Souris de lignée CBA, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Animals, Drug Evaluation, Preclinical, Female, Influenza A Virus, H9N2 Subtype (immunology), Influenza Vaccines (immunology), Mice, Mice, Inbred CBA, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control).
MESH :
- chemical , immunology : Influenza Vaccines.
- immunology : Influenza A Virus, H9N2 Subtype, Orthomyxoviridae Infections.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Drug Evaluation, Preclinical, Female, Mice, Mice, Inbred CBA.

Abstract

In this work, we examined the reassortant influenza virus strain A/17/Quail/Hong Kong/97/84 (H9N2) prepared at the Virology Department, Institute of Experimental Medicine, Russian Academy of Medical Sciences. The A/ Leningrad/134/17 (H2N2)-based vaccine candidate contained hemagglutinin and the neuraminidase from the nonpathogenic avian influenza A virus A(H9N2) of the G1 antigenic lineage. The vaccine candidate showed the ts-properties and cold adaptation. When administered intranasally to mice, the vaccine strain A(H9N2) was attenuated. It did not multiply in the lungs but was reproduced well in the nasal cavity, causing the production of the post-vaccination antibody. The A/17/Quail/Hong Kong/97/84(H9N2) virus was immunogenic when administered to mice as a LAIV intranasally or as a IIV intramuscularly. Intranasal A(H9N2) LAIV stimulated local production of the antibodies, which resulted in reduction in lung titers of the challenge virus G9.

PubMed: 26665434

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">In this work, we examined the reassortant influenza virus strain A/17/Quail/Hong Kong/97/84 (H9N2) prepared at the Virology Department, Institute of Experimental Medicine, Russian Academy of Medical Sciences. The A/ Leningrad/134/17 (H2N2)-based vaccine candidate contained hemagglutinin and the neuraminidase from the nonpathogenic avian influenza A virus A(H9N2) of the G1 antigenic lineage. The vaccine candidate showed the ts-properties and cold adaptation. When administered intranasally to mice, the vaccine strain A(H9N2) was attenuated. It did not multiply in the lungs but was reproduced well in the nasal cavity, causing the production of the post-vaccination antibody. The A/17/Quail/Hong Kong/97/84(H9N2) virus was immunogenic when administered to mice as a LAIV intranasally or as a IIV intramuscularly. Intranasal A(H9N2) LAIV stimulated local production of the antibodies, which resulted in reduction in lung titers of the challenge virus G9.</div>
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[A preclinical trial of the reassortant influenza virus vaccine strain A/17/Quail/Hong Kong/97/84 (H9N2)].

[A preclinical trial of the reassortant influenza virus vaccine strain A/17/Quail/Hong Kong/97/84 (H9N2)].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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